Colloquium in Theoretical Physics
Can a Physicist Contribute to the Understanding of Alzheimer's Disease?
Professor Anders Irbäck
- On Protein Folding, Unfolding and Misfolding
Department of Theoretical Physics, Lund University
Friday, 22nd April 2005, 13.30
Lecture hall (Sal) F, Sölvegatan 14
Many proteins are capable of folding spontaneously into their biologically
active structures. To understand the mechanism behind this folding, and
why it sometimes does not work, is a major goal in biological physics.
The "misfolding" of proteins is believed to play a role in a number of
diseases, including Alzheimer's, in which misfolded forms of proteins
accumulate or aggregate. In this talk, I will discuss how the mechanisms
of protein folding and aggregation can be investigated with the tools of
a physicist, and how essential features of these complex processes can be
understood from a simple model. The same model can also be used to
describe force-induced unfolding of proteins which is being studied
experimentally at the single-molecule level.
The Colloquia in Theoretical Physics are aimed for a general audience of
students, teachers and researchers interested in physics and the laws of
Nature. Coffee will be served after the Colloquium.
Everybody is welcome!
Gösta Gustafson -- Theoretical physics
Sven Åberg -- Mathematical physics
Last modified: Apr 8 2005