seal, Lunds universitet

Colloquium in Theoretical Physics

Can a Physicist Contribute to the Understanding of Alzheimer's Disease?
- On Protein Folding, Unfolding and Misfolding

Professor Anders Irbäck
Department of Theoretical Physics, Lund University

Friday, 22nd April 2005, 13.30
Lecture hall (Sal) F, Sölvegatan 14

Many proteins are capable of folding spontaneously into their biologically active structures. To understand the mechanism behind this folding, and why it sometimes does not work, is a major goal in biological physics. The "misfolding" of proteins is believed to play a role in a number of diseases, including Alzheimer's, in which misfolded forms of proteins accumulate or aggregate. In this talk, I will discuss how the mechanisms of protein folding and aggregation can be investigated with the tools of a physicist, and how essential features of these complex processes can be understood from a simple model. The same model can also be used to describe force-induced unfolding of proteins which is being studied experimentally at the single-molecule level.


The Colloquia in Theoretical Physics are aimed for a general audience of students, teachers and researchers interested in physics and the laws of Nature. Coffee will be served after the Colloquium.

Everybody is welcome!

Gösta Gustafson -- Theoretical physics
Sven Åberg -- Mathematical physics

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Stefan Keppeler (stefan.keppeler@matfys.lth.se)